建設(shè)內(nèi)容和目標(biāo)
協(xié)云基因在病原體分析與微生物組學(xué)方面具備國際領(lǐng)先的算法開發(fā)與應(yīng)用能力，致力于為用戶提供從樣本管理，數(shù)據(jù)管理，數(shù)據(jù)分析到定制化決策支持的微生物數(shù)字化實(shí)驗(yàn)室解決方案。
成功案例
國家流感中心流感預(yù)測預(yù)警平臺
國家CDC流感疫苗株預(yù)測平臺
檢測數(shù)據(jù)管理，分析與知識發(fā)現(xiàn)平臺
微生物樣本資源庫與實(shí)驗(yàn)室管理系統(tǒng)
微生物NGS數(shù)據(jù)分析云平臺
生物信息學(xué)資源管理系統(tǒng)
本團(tuán)隊在微生物領(lǐng)域自主研發(fā)的算法十余項(xiàng)，專利3個，PCT專利2個，軟著11個，通過與客戶進(jìn)行科研合作發(fā)表的論文三十余篇，以下為部分代表性成果展示。
自主算法
Cluster-transition determining sites underlying the antigenic evolution of seasonal influenza viruses. Molecular biology and evolution, 2019.
Generation of a live attenuated influenza vaccine that elicits broad protection in mice and ferrets. Cell host & microbe, 2017.
Evolution-informed forecasting of seasonal influenza A (H3N2). Science Translational Medicine, 2017.
Cell membrane proteins with high N-glycosylation, high expression, and multiple interaction partners are prefered by mammalian viruses as receptors. Bioinformatics?2018
Network of co-mutations in Ebola virus genome predicts the disease lethality. Cell research, 2015.
Sequential reassortments underlie diverse influenza H7N9 genotypes in China. Cell host & microbe, 2013.
客戶服務(wù)成果
Metagenomic analysis of viral nucleic acid extraction methods in respiratory clinical samples. BMC genomics, 2018.
An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network. Nature communications, 2017.
ICM: a web server for integrated clustering of multi-dimensional biomedical data. Nucleic acids research, 2016.
AAgAtlas 1.0: a human autoantigen database. Nucleic acids research, 2016.
PREDAC-H3: a user-friendly platform for antigenic surveillance of human influenza a (H3N2) virus based on hemagglutinin sequences. Bioinformatics, 2016
Clinical metagenomic analysis of bacterial communities in breast abscesses of granulomatous mastitis. International Journal of Infectious Diseases, 2016.
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